Project description:FOXM1 increases beta cell proliferation and mass in aged male mice. Previous work also demonstates that reducing Foxm1 in the beta cell had a larger effect on male than female beta cell function. Here we investigate differences in FOXM1 action in the beta cell due to sex.
Project description:FOXM1 increases beta cell proliferation and mass in aged male mice. Previous work also demonstates that reducing Foxm1 in the beta cell had a larger effect on male than female beta cell function. Here we investigate differences in FOXM1 action in the beta cell due to sex.