RNA-sequencing of genetically engineered intestinal organoid lines modeling colorectal cancer (CRC) progression

ABSTRACT: To characterize the transcriptional changes acorss the CRC malignancy continum, wild type organoids (WT), ApcKO (A) and ApcKO::KrasG12D::Smad4KO::Trp53KO (AKSP) tumoroids were subjected to bulk RNA_seq. We then performed gene expression profiling analysis using data obtained from mRNA-seq of the indicated organoid lines.

ORGANISM(S): Mus musculus

PROVIDER: GSE239754 | GEO | 2024/10/17

REPOSITORIES: GEO