Identification of host endotypes using peripheral blood transcriptomics in a prospective cohort of patients with endocarditis [pre-post_qx]

ABSTRACT: Infective endocarditis is a severe disease caused by the infection of heart valves and endocardium by pathogenic germ. Antimicrobial therapy and surgery remain the basis of treatment, and up to 50% of the patients require surgical replacement of the affected valves to control the infectious source. The objective of this work is to identify the existence of endotypes in a prospective cohort of patients with infective endocarditis. We performed a bulk RNA-seq form peripheral blood to cluster patients according to their transcriptomic profiles at diagnosis and during their follow-up. Clinical data, outcomes and response to surgery were assessed in a cluster-specific manner, in order to identify differences in the pathogenesis that could help to find personalized treatments and improve the outcome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240320 | GEO | 2023/08/08

REPOSITORIES: GEO