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Genetic regulatory axis between AGR2 and ESR1 promotes breast cancer progression

ABSTRACT: AGR2 has emerged as a key player in tumorigenesis and metastasis, exhibiting upregulation in various types of cancer and contributing to their malignant progression. Intriguingly, despite its canonical residence within the ER, this enigmatic protein possesses the ability to venture beyond cellular boundaries and manifest tumorigenic properties in the extracellular environment. This study aimed to first define the global transcriptome that is maintained by a functional AGR2 system in breast cancer cells and find potential constituents for this cancer associated process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240533 | GEO | 2026/05/31

REPOSITORIES: GEO

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Genes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2

Project description:We and others have shown that AGR2 is frequently upregulated during the development of pancreatic cancer. We used microarray to look at the target genes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2. Keywords: gene knock-down, overexpression We transiently down-regulated AGR2 expression in FA6 pancreatic cancer cells using INTERFERin transfection reagent and either AGR2 siRNA or non-targeting control siRNA for 48 hours. RNA was extracted and hybridized on Affymetrix microarrays. We looked for new target genes regulated by AGR2. We generated stable cell lines by introducing control vector pCEP4 or AGR2 overexpressing vector pCEP4-AGR2 into the pancreatic cancer cell line MiaPaCa2, single cell clones were then isolated. RNA was extracted and hybridized on Affymetrix microarrays.We looked for new target genes regulated by AGR2.

2013-07-28 | E-GEOD-12513 | biostudies-arrayexpress

Genetic regulatory axis between AGR2 and ESR1 promotes breast cancer progression

Project description:Genetic regulatory axis between AGR2 and ESR1 promotes breast cancer progression

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Genes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2

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Gene expression profile of the stomach from an AGR2 null mouse

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Exploring the mechanism of AGR2 regulating the progression of pancreatic ductal adenocarcinoma and remodeling of the tumor microenvironment

Project description:Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and lethal malignant tumor characterized by extensive desmoplasia. We found that AGR2 deletion reshapes the tumor microenvironment by affecting the activation of the IGF1 signaling pathway. On the one hand, AGR2, as an endoplasmic reticulum protein, promoted correct folding and cell surface distribution of IGF1R. On the other hand, AGR2 was secreted into the extracellular space, promoting IGF1 transcription by activating the WNT pathway in cancer-associated fibroblasts (CAFs). Through these mechanisms, AGR2 significantly enhanced the IGF1 signal in the PDAC tumor microenvironment, accelerating the formation of desmoplasia and an immunosuppressive microenvironment.

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The protein disulfide isomerase AGR2 is essential for the production of intestinal mucus

Project description:Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent homology-based search for additional PDI family members identified anterior gradient homolog 2 (AGR2), a protein originally presumed to be secreted by intestinal epithelial cells, but the function of AGR2 has been obscure. Here we show that AGR2 is expressed in the ER of secretory cells and is essential for in vivo production of intestinal mucin, a large cysteine-rich glycoprotein that forms the protective mucus gel lining the intestine. A cysteine residue within the AGR2 thioredoxin-like domain forms mixed disulfide bonds with MUC2, consistent with a direct role for AGR2 in mucin processing. Despite a complete absence of intestinal mucin, mice lacking AGR2 appeared healthy but were highly susceptible to dextran sodium sulfate-induced experimental colitis, indicating a critical role for AGR2 in protection from environmental insults. We conclude that AGR2 is a unique member of the PDI family that has a specialized and non-redundant role in intestinal mucus production. Keywords: small intestine and colon gene expression profiles for Agr2-/- and littermate control mice

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Exploring the mechanism of AGR2 regulating the progression of pancreatic ductal adenocarcinoma and remodeling of the tumor microenvironment [CUT&Tag]

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Gene expression profile of the stomach from an AGR2 null mouse

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2012-12-01 | E-GEOD-40062 | biostudies-arrayexpress

The gene regulations by AGR2 in the lung cancer cell line PC9 under Gefitinib treatment.

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