Genomic editing of pathogenic TNNI3 mutation in restrictive cardiomyopathy rescues diastolic dysfunction of human induced pluripotent stem cell-derived cardiomyocytes

ABSTRACT: To investigate the physiological characteristics of cardiomyocytes (CM) in restrictive cardiomyopathy (RCM), we established RCM(heterozygous)-iPSC and produced RCM(homozygous)-iPSC and corrected Isogenic-iPSC using CRISPER-CAS9 technology. Then, we used the RNA-seq data obtained from these three iPSCs and three different healthy iPSC-derived CMs for gene expression profiling analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240775 | GEO | 2023/08/21

REPOSITORIES: GEO