Differential gene expression in circulating leukocytes from breast cancer patients treated with Cognitive Behavioral Stress Management
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ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE24079 | GEO | 2012/01/01
SECONDARY ACCESSION(S): PRJNA130205
REPOSITORIES: GEO
Similar Datasets
Project description:Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 53 female breast cancer patients at 6- or 12-month follow-ups in a randomized controlled trial of Cognitive Behavioral Stress Management or an active control condition. The primary research question is whether gene expression differs in patients treated with Cogntive Behavioral Stress Management vs control conditions. Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 53 female breast cancer patients at 6- or 12-month follow-ups in a randomized controlled trial of Cognitive Behavioral Stress Management or an active control condition. The primary research question is whether gene expression differs in patients treated with Cogntive Behavioral Stress Management vs control conditions. Risk prediction
2012-01-01 | E-GEOD-24079 | biostudies-arrayexpress
Project description: Not available
| S-ECPF-GEOD-24079 | biostudies-other
Project description:This randomized clinical trial studies a cognitive-behavioral intervention to treat worry, uncertainty, and insomnia in cancer survivors. Counseling may reduce anxiety and insomnia as well as improve the well-being and quality of life of cancer survivors. This study also explores the neuro-immunologic correlates of anxiety and insomnia.
| 2150626 | ecrin-mdr-crc
Project description:Gene expression profiling was carried out on peripheral blood CD14+ leukocytes from 21 stressed caregivers and controls (all adult). The primary research question is whether gene expression differs in individuals from high stress vs low stress environments. SUBMITTER_CITATION: Miller, G. E., Chen, E., Sze, J., Marin, T., Doll, R., Ma, R., & Cole, S. W. (2008) A genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-kappaB signaling. In press, Biological Psychiatry. Experiment Overall Design: Gene expression profiling was carried out on peripheral blood CD14+ leukocytes from 21 stressed caregivers and controls (all adult). The primary research question is whether gene expression differs in individuals from high stress vs low stress environments.
2008-06-20 | E-GEOD-7893 | biostudies-arrayexpress
Project description:Gene expression profiling was carried out on peripheral blood CD14+ leukocytes from 21 stressed caregivers and controls (all adult). The primary research question is whether gene expression differs in individuals from high stress vs low stress environments. Keywords: Risk prediction
2008-05-20 | GSE7893 | GEO
Project description:Intervention 1: Intervention group: People in the first intervention group will receive cognitive-behavioral group therapy/ First session: Running pre-test, introduction, discussing the importance of non-pharmacological treatments, introducing the cognitive-behavioral pattern. Second session: Reviewing the tasks of the previous session, teaching behavioral techniques to control the severity of complications from cancer, teaching some ways to cope with fatigue, teaching relaxation, teaching cognitive-behavioral techniques, expressing negative emotions (such as avoiding absolutism and generalization, Analysis of profits and losses and expressing feelings along with expressing expectations) and presentation of tasks. Third Session: Reviewing the tasks of the previous session, getting to know ways to deal with problems such as denial, projection, zoom Out, magnification, catastrophizing and Intellectual ruminations , Familiarity with problem solving techniques, regular planning for activity and planning for positive affairs on a daily basis and the presentation of tasks. Fourth session: Reviewing the tasks of the previous session, familiarizing with negative thoughts including negative thinking, mind Reading and negative predictive, preparing a list of negative thoughts. Fifth session: Reviewing the tasks of the previous session, familiarizing with How to deal with negative thoughts, presenting tasks for coping with negative thoughts in everyday life. Sixth session: Reviewing to use of problem-solving interventions on everyday issues, Reviewing the past contents and summaries, providing feedback on progress and receiving feedback from the patient about successful and unsuccessful aspects of treatment, post-test implementation, and appreciation of participants. The treatment process will be 6 sessions per 90 minutes. Intervention 2: Intervention group: People in the second group of intervention will receive group therapy for psychoeducational training. The process of t
Primary outcome(s): Quality of Life. Timepoint: At baseline, after the intervention and one month later, they will be evaluated by the WHOQOL quality of life test. Method of measurement: All participants are assessed by WHOQOL Quality of Life Test.
Study Design: Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: After the convenience sampling method, the resident of psychiatry will randomly divide them into two intervention groups. Samples will be assigned by block randomization method one by one samples by using closed envelopes in two groups of 10 (With cognitive-behavioral intervention and psycho educational training). Given that the total number of samples is 20, people will be divided into 5 blocks of 4. Then assistant assigns patients to each group by closed envelopes. The first group is subjected to a cognitive-behavioral group for 6 weeks per week for a 1.5 hour session. The second group is subjected to a group of psycho educational training in six sessions per week, one 1.5 hour session.
| 2486030 | ecrin-mdr-crc
Project description:Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contributes to symptoms. We transplanted gut microbiota from human donors with ASD and TD controls into germ-free mice, and reveal that colonization with ASD microbiota was sufficient to induce hallmark autistic behaviors. The brains of mice colonized with ASD microbiota display alternative splicing of ASD-relevant genes. Microbiome and metabolome profiles of mice harboring human microbiota predict that specific bacterial taxa and their metabolites modulate ASD behaviors. Indeed, treatment of an ASD mouse model with candidate microbial metabolites improves behavioral abnormalities and affects neuronal excitability in the brain. We propose that the gut microbiome modulates behaviors in mice via production of neuroactive metabolites, suggesting that gut-brain connections contribute to the pathophysiology of ASD.
2019-07-04 | MTBLS726 | MetaboLights
Project description:Recent evidence suggests that immune checkpoint blockade (ICB) has some activity in metastatic dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS). We conducted a randomized, non-comparative phase 2 trial (NCT03307616) of nivolumab or nivolumab/ipilimumab in patients with resectable retroperitoneal DDLPS (n=17) and extremity/truncal UPS (n=10), with UPS patients receiving concurrent radiation therapy. The primary endpoint of pathologic response as assessed by percent hyalinization was observed to be a median of 8.8% in DDLPS patients and 89% in UPS patients and similar in nivolumab and ipilimumab/nivolumab arms in both cohorts . Higher intratumoral densities of T-regulatory cells were associated with absence of pathologic response (hyalinization<30%). Tumor infiltration by B-cells was associated with higher densities of T-regulatory cells before treatment; this association was lost upon ICB treatment. Our data demonstrate that neoadjuvant ICB with concurrent radiation may have significant efficacy in UPS and is associated complex immune changes in the tumor microenvironment in DDLPS and UPS.
2024-01-01 | GSE202361 | GEO
Project description:Recent microarray studies in the hippocampus of rodents or Alzheimerâs disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. These were correlated with performance scores on the hippocampus-dependent Morris Water Maze task. Significant microarray results were sorted in to Early, Intermediate, Midlife, and Late patterns of expression, and functionally categorized (Early- downregulated neural development, lipid synthesis and energy-utilization; upregulated ribosomal synthesis, growth, stress/inflammatory, lysosome and protein/lipid degradation. Intermediate- increased defense/inflammatory activation and decreased transporter activity; Midlife- downregulated energy-dependent signaling and neurite growth, upregulated astroglial activation, Ca2+-binding, cholesterol/lipid trafficking, myelinogenic processes and additional lysosome/inflammation; Late- further recruitment of genes in already-altered pathways). Immunohistochemistry revealed a primarily astrocytic localization of the processes upregulated in midlife, as well as increased density of myelin proteins. Evidence of cognitive impairment first appeared in the 12-month-old group (midlife) and was increased further in the 23-month-old group, exhibiting the highest correlations with some upregulated genes related to cholesterol transport (e.g., Apoe, Abca2), protein management and ion binding. Some upregulated genes for inflammation (Il6st) and myelinogenesis (Pmp22) also correlated with impairment. Together, the data are consistent with a novel sequential cascade model of brain aging in which metabolic alterations early in maturity are followed by inflammation and midlife activation of an astrocyte-centered cholesterol trafficking pathway that stimulates oligodendrocyte remyelination programs. Importantly, this cholesterol trafficking pathway also may compete for astroglial bioenergetic support of neurons, in turn, leading to downregulation of energy-dependent pathways needed to sustain cognitive functions. Experiment Overall Design: Fisher 344 rats aged 3 (n = 9), 6 (n = 9), 9 (n = 9), 12 (n = 9), or 25 (n = 15; but see below) months were behaviorally characterized on the Morris water maze. Briefly, animals were placed in a circular water bath chamber with a partially submerged platform. Three times per day for three days, animals were placed at randomized starting points with the goal of locating the hidden platform. Generally, animals became better at locating the platform, and by the third day of training, were reliably swimming directly to the platform despite randomized starting loci. On the fourth day, the platform was removed and the degree to which the animals focused their searches on the area that previously contained the platform was measured. On the last day of behavior, animals were given a cue trial in which the platform was raised above the water level so that the rats could see it. Measures taken from the behavior study included path length (how long did the animal swim prior to locating the platform/ platform area), latency to platform in seconds, and velocity (centimeters/ second; swim speed). Two aged animals (E2 and E12) were removed from the study for poor health, reducing the 23 month cohort (n = 13). Twelve to twenty four hours after the last behavioral session, animals were killed and their hippocampi removed. The right hippocampus went to immunohistochemistry for quantification and localization of selected protein products. The left hippocampus was dissected, the CA1 region removed and frozen in dry ice prior to microarray processing. mRNA was extracted from each animal's tissue by standard Affymetrix protocols (see Blalock et al., 2003) and hybridized to individual microarrays (RAE 230A; N = 49 arrays in total). Results were processed with the MAS5 algorithm and subjected to âall probe setâ scaling with a target intensity of 500. Probe sets were filtered for presence (> = 5 presence calls study wide) and gene symbol level annotation prior to statistical analysis. 1-ANOVA across age was used to identify aging-related probe sets/genes (p <= 0.05). Aging-related genes were subjected to post hoc template correlation to determine the pattern of age-related change, and further, within the 12 and 23 month old groups, Pearson's correlation with behavioral scores was used to identify genes whose expression levels correlated significantly (p <= 0.05) with behavior. Twelve and 23 month old groups were chosen for this correlation analysis as they showed the greatest variability among similarly aged animals, suggesting that these ages show important cognitive transition phases during aging-related cognitive decline. Functional grouping analysis was performed using the DAVID suite of on-line tools.
2009-01-25 | E-GEOD-9990 | biostudies-arrayexpress
Project description:Intervention group:Virtual-reality based Cognitive Behavioral Intervention ;Attention Control group:Dietary guidance
Primary outcome(s): The sick role adaptation
Study Design: Parallel
| 88803 | ecrin-mdr-crc