Whole genome microarray gene expression profiling of transgenic mouse hearts with four-fold increased BBLN contents

ABSTRACT: The study performed whole genome microarray gene expression profiling of mouse hearts from BBLN-transgenic mice with four-fold increased cardiac BBLN (Bublin coiled coil protein) contents (Tg-BBLN-low) in comparison to non-transgenic FVB hearts. Tg-BBLN-low mice with four-fold increased cardiac BBLN expression under control of the myocardium-specific alpha-MHC promoter developed features of compensated heart failure with increasing age, which was characterized by a significantly reduced left ventricular ejection fraction as determined by echocardiography. To investigate the compensated heart failure phenotype of Tg-BBLN-low mice, whole genome micoarray gene expression profiling was performed. The microarray data show that moderately increased cardiac BBLN levels are sufficient to induce features of pathological cardiac remodeling.

ORGANISM(S): Mus musculus

PROVIDER: GSE241030 | GEO | 2023/09/18

REPOSITORIES: GEO