Tppp3 acts as a new therapeutic gene for optic nerve regeneration

ABSTRACT: In this study, we investigated the role of Tppp3 overexpression on axon regeneration and RGC survival in a mouse optic nerve crush model. We observed that Tppp3 overexpression upregulates expression levels of axon regeneration-induced genes and cellular pathways, such as BMP4 and neuroinflammation, thereby resulting in improved RGC survival and axon regeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE241230 | GEO | 2025/02/01

REPOSITORIES: GEO