Effect of depletion of HMOX1 on gene expression of AsPC-1 cells.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Endoplasmic reticulum stress plays an essential role in PDAC progression. Here, we aim to identify the ERS-related genes in PDAC and build reliable risk models for diagnosis, prognosis and immunotherapy response of PDAC patients. We report HMOX1 as an important gene of ER stress related-signature we established in PDAC. The depletion of HMOX1 results in tumor growth inhibition. Our data lay the foundation for further investigating the potential mechanism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE241352 | GEO | 2023/08/24

REPOSITORIES: GEO