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Transcriptome Analysis of Differentially Expressed Genes in the Wild-type and Fabp7 KO Mouse Inner Ear

ABSTRACT: To reveal the function of FABP7 in the inner ear, we evaluated gene expressions between Wild-type and Fabp7 KO mice one day after noise exposure at 10 weeks, using RNA sequencing analysis. The read number was approximately 27–32 million paired-end reads per sample. A total of 24 and 23 genes were identified as upregulated and downregulated differentially expressed genes (DEGs), respectively in Fabp7 KO mice. The upregulation of genes related to nicotinamide-adenine dinucleotide (NADH) dehydrogenase (mt-Nd1, 2, 3, 4, and 6) and a glial high-affinity glutamate transporter (solute carrier family 1, member 2: Slc1a2) and downregulation of genes related to C/D box small nucleolar RNAs were observed in Fabp7 KO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE241529 | GEO | 2023/11/22

REPOSITORIES: GEO

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Comprehensive transcriptome analysis of the cochleae of 7-month-old Fabp7 (+/+) and Fabp7 (-/-) mice

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Mus musculus

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