Enhancer-activated RET confers protection against oxidative stress to the MLL-rearranged acute myeloid leukemia cells

ABSTRACT: RET expression is upregulated in AML subtypes harboring genetic fusions of MLL-1 genes compared to age-matched healthy donors and other AML subtypes. In addition, we identify a novel epigenetic mechanism of RET overexpression in MLL-rearranged AML.

ORGANISM(S): Homo sapiens

PROVIDER: GSE241738 | GEO | 2024/03/04

REPOSITORIES: GEO