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Regulatory and epistatic networks unravel the complexity of piebald, a pigmentation phenotype in Merino sheep

ABSTRACT: Transcriptional profiling of Ovine skin samples comparing pigmentation samples from piebald and normal Merino sheep

ORGANISM(S): Bos taurus Ovis aries

PROVIDER: GSE24189 | GEO | 2010/09/18

SECONDARY ACCESSION(S): PRJNA130155

REPOSITORIES: GEO

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Regulatory and epistatic networks unravel the complexity of piebald, a pigmentation phenotype in Merino sheep

Project description:Transcriptional profiling of Ovine skin samples comparing pigmentation samples from piebald and normal Merino sheep All pair comparison of 5 pigmentation samples with dye swaps. Dye swaps were performed with different biological replicates (labelled 1 or 2) NOR - White sample from a normal, non-affected wild-type individual sheep PBB - Black sample from a piebald individual sheep PBW - White sample from a piebald individual sheep RSB - Black sample from a recessive black sheep RSW - White sample from a recissive black sheep taken from the inguinal, non-pigmented area.

2010-09-18 | E-GEOD-24189 | biostudies-arrayexpress

Does an immune response at the Ileum contribute to severity and development of helminth-diarrhoea in Merino sheep (ileum)?

Project description:Purpose: To investigaet whether an inflammatory immune response at the Ileum can contribute to development and severity of diarrhoea in Merino sheep that are prone and not prone to develop diarrhoea. Methods:Transcriptomes in the Ileum (third part of small intestine) of Merino sheep were analyzed using RNASeq. Functional enrichment of DEGs using GO terms in biological processes and KEGG pathways were studied. PPI (protein-protein interaction) network and sub-network were studied using clusterONE plugin in Cytoscape. Result and conclusion: Although Ileum in not a primary site of helminth (species under study in our experiment), the results indicated that an inflammatory immune response can contribute to development and severity of diarrhoea. The low-diarrhoea animals did not show any signs of immune/inflammatory response. The genes with important roles in the responses to helminth infection could be targeted in breeding programs to prevent diarrhoea.

2022-06-27 | GSE179149 | GEO

Ovis aries breed:Alpine merino sheep

Project description:Ovis aries breed:Alpine merino sheep Transcriptome or Gene expression

| PRJNA299731 | ENA

Does a hypersensitive immune response to helminth infection at duodenum make Merino sheep susceptible to diarrhoea?

Project description:Purpose:To explore the underlying biological mechanisms relating to development and control of diarrhoea, we compared sheep that were prone to develop diarrhoea with sheep that were not prone. Methods:Transcriptomes in the tissues of Merino sheep where the parasites were located were analyzed using RNASeq. Functional enrichment of DEGs using GO terms in biological processes and KEGG pathways were studied. PPI (protein-protein interaction) network and sub-network were studied using clusterONE plugin in Cytoscape. Result and conclusion: Our results indicate that suppression of ‘immune response’, ‘antigen processing and presentation’, and a list of biological functional terms related to ‘suppression in immune tolerance and activation of repair processes associated with tissue damage, including ‘extracellular matrix organization’, ‘collagen fibril organization’, ‘tissue morphogenesis’, ‘circulatory system development’, ‘morphogenesis of an epithelium’, and ‘focal adhesion’ were associated with high-diarrhoea phenotype. The genes with important roles in the responses to helminth infection could be targeted in breeding programs to prevent diarrhoea.

2022-06-10 | GSE176569 | GEO

Preliminary cell culture models for subclinical mastitis in sheep

Project description:Ovine mastitis is defined as the inflammation of the sheep udder, most commonly caused in response to intramammary infections. Based on the occurrence of clinical signs, mastitis is characterized as either clinical or subclinical (SCM). The impact of ovine SCM on the overall sustainability of dairy sheep farms has been documented underpinning the significance of efficient diagnosis. Although SCM can be detected in cows, the performance and the validity of the methods used do not transfer in dairy sheep. This fact challenges the development of evidence-based ovine udder health management protocols and renders the detection and control of ovine mastitis rather problematic. Currently, cell culture-based models are being successfully used in biomedical studies and have also been effectively used in the case of bovine mastitis. The objective of the present study was to culture ovine primary mammary cells for the development of 2D and 3D cell culture-based models for the study of ovine SCM. Cells were infected by mastitis-inducing pathogens mimicking the pathogenesis of SCM as derived by natural intramammary infections. The secreted proteins were subjected to mass-spectrometry resulting in the identification of 79 distinct proteins. Among those, several had already been identified in healthy or mastitic milk, while others were detected for the first time in the ovine mammary secretome. The development of cell-based models for the early detection and the overall study of SCM has the potential to be applicable and beneficial for the udder health management in dairy sheep.

2022-11-03 | PXD036985 | Pride

Using regulatory and epistatic networks to extend the findings of a genome scan: identifying the gene drivers of pigmentation in merino sheep.

Project description: Not available

| S-EPMC3119053 | biostudies-literature

Whole transcriptome profiles during sheep skeletal muscle development

Project description:Herein we present spatialtemporal profiles and performed a detailed data analysis in longissimum dorsi muscle of Chinese merino sheep at embryonic ages D85, D105, and D135. This is the first report of myogenic differentiaion and muscle fibre formation at the whole transcriptome level. The objective herein was to evaluate the whole transcriptome profiles and to develop an indepth and systematic understanding of molecular genetic controls underlying myofibre proliferation and differentiation in sheep. This report provides an effective reference for the study of non-coding RNA in other agricultural animals.

2019-11-18 | GSE127287 | GEO

Genome-wide association studies for sheep growth and meat production traits using Illumina OvineSNP50 BeadChip

Project description:Mear prodution is the most important trait for sheep. In this study, we performed a Genome-wide association study (GWAS) by using Illumina Ovine SNP50 BeadChip in 329 purebred sheep phenotyped for 11 growth and meat production traits (birth weight, weaning weight, 6-month weight, eye muscle area, fat thickness, pre-weaning gain, post-weaning gain, daily weight gain, height at withers , chest girth and shin circumference). A total of 319 sheep and 48,198 SNPs were fitted using TASSEL 3.0 software as random effects in a mixed linear model. 36 chromosome-wise significant SNPs were identified for 7 traits and 10 of them reached genome-wide significance level consistently for post-weaning gain. Gene annotation was implemented based on the latest version3.1 ovine genome sequence (released October 2012), and meanwhile we referenced genomic information of human, bovine, mouse and rat. More than one-third SNPs (14 out of 36) were located within ovine genes , some other were located close to ovine genes (878bp-398165bp apart).

2015-05-01 | GSE46231 | GEO

Genome-wide association studies for sheep growth and meat production traits using Illumina OvineSNP50 BeadChip

2015-05-01 | E-GEOD-46231 | biostudies-arrayexpress

FBLN1 and FABP4 are drivers of resistance to fleece rot in Australian Merino sheep

Project description:Transcriptional profiling of Ovine skin samples comparing resistant (RES) to susceptible (SUS) animals following fleece rot induction.

2010-03-25 | GSE21022 | GEO

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