Long read transcriptome sequencing of ccRCC tumour cell line RCC4

ABSTRACT: Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. To date, long-read RNA sequencing has not been applied to kidney cancer. Here, we used ONT long-read Direct RNA sequencing to profile the transcriptomes of ccRCC cell line RCC4, with and without exposure to pro-inflammatory cytokines. Our results revealed differentially expressed genes induced by the pro-inflammatory cytokines. Moreover, results here revealed potential tumour origin of novel isoforms and genes that were discovered in the archival tumour samples by long-read sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE242084 | GEO | 2023/09/04

REPOSITORIES: GEO