An abundance of binary promoter switches in lineage-determining transcription factors indicates a digital component of cell fate determination

ABSTRACT: An examination of transcription factor genes revealed an abundance of convergent and divergent sense/antisense promoter pairs, suggesting that competing promoters may control cell fate determination. We used 5' single cell RNAseq (5' scRNAseq) to examine divergent and convergent transcription in CD34+ hematopoietic progenitors, freshly purified innate lymphocytes from tonisl, and peripheral blood NK cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE242100 | GEO | 2023/10/27

REPOSITORIES: GEO