Transcriptomics

Dataset Information

0

MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma


ABSTRACT: Neuroblastoma is a childhood cancer believed to result from dysfunctional development. Its origin during embryogenesis remains poorly understood. The lack of appropriate models has hindered in-depth mapping of early tumor-driving events. Here, we identify a novel tumor suppressor gene associating with worse outcome in MOXD1-deprived high-risk patients, by applying bulk and single cell RNA sequencing data of neuroblastoma and human fetal adrenal glands. Trunk neural crest-specific MOXD1 discriminates cell populations during normal and tumor development, with implications for deciphering neuroblastoma cell origin. We created an embryonic conditional knockout model and show that cell type-specific loss of MOXD1 leads to disrupted organ homeostasis and failed adrenal gland formation, home for neuroblastoma. We show that MOXD1 is a tumor suppressor gene in zebrafish, chick, and mice in vivo models.

ORGANISM(S): Homo sapiens

PROVIDER: GSE242157 | GEO | 2023/09/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-02-01 | GSE162238 | GEO
| S-EPMC5333895 | biostudies-other
2019-05-24 | E-MTAB-7086 | biostudies-arrayexpress
2021-01-14 | GSE147821 | GEO
| EGAS00001004388 | EGA
2024-09-13 | GSE245175 | GEO
2022-03-09 | GSE169280 | GEO
2012-03-31 | E-GEOD-32386 | biostudies-arrayexpress
| S-EPMC6966601 | biostudies-literature
| S-EPMC2238753 | biostudies-literature