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Gene and exon expression change in cardiac hypertrophy with pressure overload

ABSTRACT: Pathological cardiac hypertrophy was induced by pressure overload on the heart. We performed genome-wide exon array experiments with left ventricles of mice with 1 week and 4 week of transverse aortic constriction (TAC). The exon level analysis revealed widespread regulation of alternative splicing and alternative polyadenylation during hypertrophy.

ORGANISM(S): Mus musculus

PROVIDER: GSE24242 | GEO | 2011/05/01

SECONDARY ACCESSION(S): PRJNA133015

REPOSITORIES: GEO

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Gene and exon expression change in cardiac hypertrophy with pressure overload

Project description:Pathological cardiac hypertrophy was induced by pressure overload on the heart. We performed genome-wide exon array experiments with left ventricles of mice with 1 week and 4 week of transverse aortic constriction (TAC). The exon level analysis revealed widespread regulation of alternative splicing and alternative polyadenylation during hypertrophy. Exon and gene expression changes were examined in 1 week and 4 week TAC-operated hearts compared to sham-operated hearts. We used C57/BL6 wildtype mice, and their left ventricles were subject to surgery (each n=2).

2011-05-01 | E-GEOD-24242 | biostudies-arrayexpress

Endogenous Muscle Atrophy F-box Regulates Pressure Overload-Induced Cardiac Hypertrophy

Project description:Muscle atrophy F-box (MAFbx) is an E3 ubiquitin ligase which plays a critical role in mediating skeletal muscle atrophy. We investigated the effect of MAFbx KO in cardiac hypertrophy in response to pressure overload. A DNA microarray analysis was conducted using total RNA prepared from wild type and MAFbx KO mouse hearts subject to transverse aortic constriction (TAC). Results provide insight into the molecular mechanism to mediate the effect of MAFbx upon pathological hypertrophy. We applied TAC to wild type and MAFbx KO mice, and extracted total RNA one week after the surgery. The gene expression profiles were examined by Affymetrix Mouse Gene ST Array.

2011-05-01 | E-GEOD-24372 | biostudies-arrayexpress

Pressure overload cardiac hypertrophy

Project description:Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 8-10 weeks month old males and females. Hearts examined 30 weeks after surgery. Keywords: ordered

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Endogenous Muscle Atrophy F-box Regulates Pressure Overload-Induced Cardiac Hypertrophy

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Transcriptome analysis of cardiac hypertrophy

Project description:RNA sequencing (RNA-seq) on polyadenylated transcripts extracted from cardiomyocytes isolated from mice after 1 week of transverse aortic constriction (TAC) and in control mice (sham). 2-month-old male C57BL/6J mice were subjected under anesthesia to transverse aortic constriction for 1 week, then we performed RNA-seq on isolated cardiomyocytes

2013-11-30 | E-MTAB-1507 | biostudies-arrayexpress

expression data from Zbtb17 cKO mouse heart after pressure overload

2013-09-06 | GSE50638 | GEO

Dynamic adaptation of myocardial proteome during heart failure development after induction of left ventricular pressure overload in mice

Project description:We analyzed time dependent global proteomic adaptations during heart failure (HF) progression in a mouse model, suffering from left ventricular pressure overload due to transverse aortic constriction (TAC), to gain deeper insights in the disease development and identify new biomarker candidates. The hearts from TAC and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n=6 group/time point). At each time point, proteomes of the left (LV) and right ventricles (RV) of TAC and sham mice were analyzed by mass spectrometry (MS).

2018-07-16 | PXD007171 | Pride

expression data from Zbtb17 cKO mouse heart after pressure overload

Project description:whole gene expression analysis for ZBTB17 cKO mice after transverse aortic constriction (TAC) We used microarrays to detail the global programme of gene expression underlying hypertrophy and heart failure process upon pressure overload 16 male mice, 4 mice per group, were selected at 8-10 weeks old for 4 weeks of TAC and SHAM and collected samples for RNA extraction and hybridization on Affymetrix microarrays. We included corresponding controls.

2013-09-06 | E-GEOD-50638 | biostudies-arrayexpress

Aberrantly expressed microRNAs participate in cardiac hypertrophy by modulating multiple signaling pathways

Project description:The expressed difference of aberrant microRNAs was successfully constructed through detection in a rat model of cardiac hypertrophy,which had been subjected to transverse aortic constriction surgery. In this study, the expressed situation of aberrant microRNAs was measured in a rat model of cardiac hypertrophy. The survey was contucted in the rats 5, 10, 15 or 20 days later after TAC surgery.

2012-06-08 | E-GEOD-38599 | biostudies-arrayexpress

Genome-wide mapping of histone H3 modifications in cardiac hypertrophy

Project description:ChIP-Sequencing using antibody to H3K9ac,H3K27ac,H3K4me3, H3K79me2, H3K9me2, H3K9me3 and H3K27me3 in cardiomyocytes isolated from mice after 1 week of transverse aortic constriction (TAC) and in control mice (sham).

2013-11-30 | E-MTAB-1506 | biostudies-arrayexpress

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