Transcriptomics

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Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis


ABSTRACT: Single-cell RNA sequencing (scRNA-seq) was performed to investigate fibroblast–myeloid cell crosstalk in lung fibrosis. The dataset includes murine lung macrophage–fibroblast cocultures or fibroblast monocultures, with macrophages derived from WT mice and fibroblasts from either WT or fibroblast-specific P2rx4 knockout (Pdgfrb-Cre: P2rx4 f/f) mice 7 days after bleomycin injury. Cells were captured using the Fluent Biosciences PIPseq platform. Data include gene–cell count matrices and support the study “Myeloid–mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis” (Yadav et al., 2025).

ORGANISM(S): Mus musculus

PROVIDER: GSE242510 | GEO | 2025/08/15

REPOSITORIES: GEO

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