Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data for PAR-1-positive and -negative melanoma cell lines

ABSTRACT: PAR-1 is known to be involved in the transition from non-metastatic to metastatic melanoma. We sought to determine the downstream target genes regulated by PAR-1 to determine how PAR-1 is contributing to the metastatic melanoma phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE24259 | GEO | 2010/09/22

SECONDARY ACCESSION(S): PRJNA132985

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data for PAR-1-positive and -negative melanoma cell lines

Project description:PAR-1 is known to be involved in the transition from non-metastatic to metastatic melanoma. We sought to determine the downstream target genes regulated by PAR-1 to determine how PAR-1 is contributing to the metastatic melanoma phenotype. The A375SM metastatic melanoma cell line was subjected to stable transduction of lentiviral-delivered small hairpin RNA (shRNA) targeting PAR-1. As a control, a non-targeting shRNA sequence (no homology to any human gene) was also transduced into A375SM cells.

2010-09-22 | E-GEOD-24259 | biostudies-arrayexpress

Expression data for PAR-1-positive and -negative melanoma cell lines

Project description: Not available

| S-ECPF-GEOD-24259 | biostudies-other

PAR-CLIP-seq reveals RNAs directly interacting with CTCF in human transformed cell line U2OS

Project description:This experiment sought to determine the genome-wide interactome of CTCF in human cells. PAR-CLIP seq for CTCF was performed in U2OS cells in 2 biological replicates

2014-03-18 | E-GEOD-53554 | biostudies-arrayexpress

Copy number analysis of recurrent metastatic melanoma lesions

2013-12-31 | GSE38137 | GEO

Gene expression analysis of recurrent metastatic melanoma lesions

2013-12-31 | GSE38119 | GEO

Human melanoma samples comparing nevi and primary and metastatic melanoma

Project description:We sought to identify genes and gene signatures which correlate with progression by sampling human melanomas from nevi, primary, and metastatic tumors. The large number of samples also permits analysis within groups. Human melanoma samples were isolated from historical frozen patient specimens. RNA was extracted and run on the human Affymetrix U133A microarray chip.

2013-05-01 | E-GEOD-46517 | biostudies-arrayexpress

Analysis of open chromatin structures in M229-Par and M229-Res cells by ATAC seq analysis .

Project description:Briefly, Melanoma M229-Par and M229-Res were analysed for open chromatin structures using ATAC seq Analysis.

2022-07-07 | GSE202117 | GEO

Analysis of M229-Par and M229-Res cells by Illumina HiSeq instrument (4000 or equivalent) seq analysis .

Project description:Briefly, Melanoma M229-Par and M229-Res were analysed for transcriptional changes using RNA seq Analysis.

2022-07-07 | GSE202118 | GEO

Gene Expression Patterns Involved in the Malignant Transformation and Progression of Metastatic Melanoma

Project description:Metastatic melanoma is a deadly disease while non-metastatic melanoma and other cutaneous tumor types are usually cured with surgical removal of the primary tumors. This study evaluated gene expresion to determine if gene expression differences existed which would allow one to identify the metastatic tumors based on the expression of specific genes. Keywords: multiple tissue comparison

2008-05-28 | GSE7553 | GEO

Gene expression analysis of recurrent metastatic melanoma lesions

Project description:In this study, we sought to indentify stable individual traits in developing metastatic melanoma, assess their stability in time, and analyze typical dynamics and common trends of genomic changes in individual cases of late stage metastatic cancer. To this end, we compared consecutive recurrent metastases developed by a special group of eight individuals with advanced metastatic melanoma, all developing several recurrent metastases over several months to years of natural disease evolution. Twenty-six recurrent melanoma metastases were surgically isolated from 8 patients experiencing relapse after one or more successful treatment intervention(s) with no signs of residual disease. Patients experiencing recurrent metastases were labeled with capital letters; M-bM-^@M-^\AM-bM-^@M-^], M-bM-^@M-^\BM-bM-^@M-^], M-bM-^@M-^\CM-bM-^@M-^], etc., their subsequent metastases as M-bM-^@M-^\A/1M-bM-^@M-^], M-bM-^@M-^\A/2M-bM-^@M-^], M-bM-^@M-^\B/1M-bM-^@M-^], M-bM-^@M-^\B/2M-bM-^@M-^], etc., while synchronous metastases in a given patient were labeled as M-bM-^@M-^\A/1aM-bM-^@M-^], M-bM-^@M-^\A/1bM-bM-^@M-^] etc. Another 22 melanoma cell lines isolated and maintained as above were expanded from melanoma patients with rapid disease curse, for whom only one metastasis was available. As no extended follow up was possible in these cases, the cell lines are considered representative of random time points in the natural course of metastatic melanoma. These cell lines were labeled with Arabic numbers, as M-bM-^@M-^\1M-bM-^@M-^], M-bM-^@M-^\2M-bM-^@M-^], M-bM-^@M-^]3M-bM-^@M-^], etc

2013-12-31 | E-GEOD-38119 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data