A domino effect in drug action: From metabolic assault towards parasite differentiation

ABSTRACT: Glycolysis is the sole free-energy source for the deadly parasite Trypanosoma brucei and is therefore a possible target pathway for anti-trypanosomal drugs. Plasma-membrane glucose transport exerts high control over trypanosome glycolysis and hence the transporter is a promising drug target. Here we show that at high inhibitor concentrations, inhibition of trypanosome glucose transport causes cell death. Most interestingly, sublethal concentrations initiate a domino effect in which network adaptations enhance inhibition.

ORGANISM(S): Trypanosoma brucei

PROVIDER: GSE24275 | GEO | 2010/10/18

SECONDARY ACCESSION(S): PRJNA133013

REPOSITORIES: GEO