Muscle miRNAs are influenced by sex at baseline and in response to exercise

ABSTRACT: The aim of this study was to investigate the effect of sex on miRNA expression in skeletal muscle. MiRNAs were first screened using Taqman®miRNA arrays in skeletal muscle of 42 healthy participants from the Gene SMART study (23 males and 19 females aged 18-45 yrs). Based on this 2 candidate miRNAs, hsa-miRNA-30a-5p (miR-30a) and hsa-miRNA-30c-5p (miR-30c), were overexpressed in three female and three male primary skeletal muscle lines. Overexpression of miR-30a and miR-30c was confirmed by quantifying transcript levels using qPCR RNA sequencing to understand the transcriptome profile changes driven by these miRNAs and to explore the putative biological pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE242861 | GEO | 2023/10/05

REPOSITORIES: GEO