Genomics

Dataset Information

0

Athsq1 is linked to Cdkn2a


ABSTRACT: Common genetic variants in a 58-kilobase (kb) region of chromosome 9p21, near the CDKN2A/B cell proliferation inhibitor genes, are strongly associated with coronary artery disease (CAD). We previously reported a congenic mouse model harboring an atherosclerosis susceptibility locus in a region of homology with the human 9p21 locus. We now report markedly decreased Cdkn2a (cyclin-dependent kinase inhibitor 2a) mRNA expression in macrophages and increased circulating levels of Ly6Chigh inflammatory monocytes in congenic mice compared to controls. A bone marrow (BM) transplantation study revealed that BM-derived cells from Cdkn2a+/- mice are capable of conferring accelerated atherosclerosis, increased inflammatory monocyte subsets and monocyte proliferation in the Ldlr-/- mouse model. These findings provide a mechanistic link between decreased expression of Cdkn2a transcripts, increased monocyte proliferation, and accelerated atherosclerosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE24342 | GEO | 2011/10/01

SECONDARY ACCESSION(S): PRJNA132903

REPOSITORIES: GEO

Similar Datasets

2011-09-30 | E-GEOD-24342 | biostudies-arrayexpress
2023-06-06 | GSE211779 | GEO
2008-01-25 | GSE9023 | GEO
2019-12-03 | GSE107645 | GEO
2008-01-24 | E-GEOD-9023 | biostudies-arrayexpress
2017-07-05 | GSE100786 | GEO
2020-09-21 | GSE121696 | GEO
2021-12-05 | GSE186528 | GEO
2009-11-16 | GSE16706 | GEO
2016-06-10 | PXD001769 | Pride