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EMA2 is required for target-directed scnRNA degradation.

ABSTRACT: Piwi-associated small RNAs of the ciliated protozoan Tetrahymena uses such mechanism to induce heterochromatin formation followed by programmed DNA elimination. In this process, target-directed small RNA degradation (TDSD) of small RNAs complementary to the somatic genome enables small RNAs to specifically target the germline-limited sequences for DNA elimination. The data here indicate that the SUMO E3 ligase Ema2 is required for the accumulation of long non-coding RNAs (lncRNAs) from the somatic genome and thus for TDSD.

ORGANISM(S): Tetrahymena thermophila

PROVIDER: GSE243435 | GEO | 2023/09/18

REPOSITORIES: GEO

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