3D structure of the genome of F. graminearum strain PH-1
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ABSTRACT: Fusarium graminearum is an efficient plant pathogen found in crops worldwide. Major causal agent of Fusarium head blight on wheat in Europe, this filamentous fungus can also produce toxic mycotoxins and a variety of secondary metabolites in developing kernels. These secondary metabolites are produced as the result of a cascade of coordinated regulations of an arsenal of genes dispersed accross the genome. Previous study highlighted the roles of the histone marks H3K27me3 and H3K4me3 in regulating the metabolism of F. graminearum. Here, we applied HiC in combination to transcriptomics to explore the functional components of 3D organization of the four chromosomes in the nucleus. We show that the orchestration of genome regulation is mediated by histone-dependant highly topologically structured chromatin that organizes chromosomes in territories to potentiate coordinated genome regulation.
ORGANISM(S): Fusarium graminearum
PROVIDER: GSE243436 | GEO | 2024/09/14
REPOSITORIES: GEO
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