Single cell RNA profiling of neutrophils in a model of pancreatic orthotopic cancer

ABSTRACT: Neutrophils are increasingly recognized as key players in the tumour immune response, and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Single-cell RNA sequencing (scRNAseq) of neutrophils from the bone marrow, spleen, and blood in addtion to the pancreatic tumor thus uncovers an unique tumor differentiation trajectory, where immature and mature neutrophils converge into a terminally differentiated tumor neutrophil state.

ORGANISM(S): Mus musculus

PROVIDER: GSE243466 | GEO | 2024/01/11

REPOSITORIES: GEO