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Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enchanced self-renewal potential [scRNA-Seq]

ABSTRACT: We used scRNA-seq to examine the cellular and molecular alterations between 3D organoids generated from esophageal epithelial cells with low and high autophagic vesicle content.

ORGANISM(S): Mus musculus

PROVIDER: GSE243580 | GEO | 2023/09/20

REPOSITORIES: GEO

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Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enchanced self-renewal potential [RNA-Seq]

Project description:We used bulk RNA-seq to examine the molecular alterations between esophageal epithelial cells with low and high autophagic vesicle content.

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Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enchanced self-renewal potential

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Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enchanced self-renewal potential

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Project description:In this second part of the project “Profiling of purified autophagic vesicle content and degradome in the maturing and aging brain” four label-free proteomics studies were performed to characterize stabilization of potential autophagy targets upon lysosomal and/or autophagy inhibition.

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