Genomics

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Inhibition of BCL6-dependent gene expression in Philadelphia chromosome positive acute lymphoblastic leukemia


ABSTRACT: The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. Tyrosine kinase inhibitors (TKI) are widely used to treat patients with leukemia driven by BCR-ABL1 and other oncogenic tyrosine kinases. In response to TKI-treatment, BCR-ABL1 ALL cells upregulate BCL6 protein levels by ~90-fold, i.e. to similar levels as in diffuse large B cell lymphoma (DLBCL) with BCL6 translocations. In this study, we analyzed the gene expression changes after treatment with Imatinib or Imatinib + RI-BPI.

ORGANISM(S): Homo sapiens

PROVIDER: GSE24381 | GEO | 2011/03/01

SECONDARY ACCESSION(S): PRJNA133471

REPOSITORIES: GEO

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