Single-cell transcriptomic characterization of immune cells from livers of wild type and ATF6 transgenic mice

ABSTRACT: Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF6α) remains unclear. We isolated CD45+ cells from livers of wild type and hepatocyte-specific nATF6 overexprerssion mice for scRNAseq to decrible the the immune cell population.

ORGANISM(S): Mus musculus

PROVIDER: GSE243826 | GEO | 2025/11/05

REPOSITORIES: GEO