Response of the amnion to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque

ABSTRACT: We demonstrate that during chorioamnionitis the amnion transcriptome is dominated by immune and inflammation related genes, largely driven by the NF-kB pathway. The amnion mesenchymal cells expressing We demonstrated that during chorioamnionitis the amnion transcriptome is dominated by immune and inflammation related genes, largely driven by the NF-kB pathway. CD14 and other myeloid cell markers increase in number with increased expression of innate immune activation markers during intrauterine infections.

ORGANISM(S): Homo sapiens Macaca mulatta

PROVIDER: GSE243830 | GEO | 2023/09/23

REPOSITORIES: GEO