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Airway Microfold (M) Cells Emerge in the Post-IAV Lung

ABSTRACT: Airway cell fates are altered during repair and regeneration following lung injury. Here we survey mouse airway epithelium using single nucleus RNA-sequencing after influenza (PR8) infection and uncovered the emergence of Microfold (M) cells in the post-IAV intrapulmonary lung. These pulmonary M cells share expression signatures with the better-characterized intestinal M cells. Furthermore, similar to intestinal M cells that function by overlying lymphoid follicles in Peyer’s Patches, the post-IAV pulmonary M cells are enriched over bronchus associated lymphoid tissue (BALT), suggestive an interactive relationship.

ORGANISM(S): Mus musculus

PROVIDER: GSE244279 | GEO | 2024/01/11

REPOSITORIES: GEO

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