ScRNA-Seq of bovine fetal testes derived from NANOS3 knockout and wildtype embryos

ABSTRACT: We performed single cell RNA-sequencing (scRNA-Seq) of testes from bovine fetuses derived from either CRISPR/Cas9 NANOS3 knockout (KO; NANOS3 -/-) or wildtype control (NANOS3 +/+) embryos. The scRNA-Seq analysis showed a complete loss of primordial germ cells (PGCs) and gonocytes in NANOS3 KO fetal testes, while maintaining the development of somatic support cells.

ORGANISM(S): Bos taurus

PROVIDER: GSE244321 | GEO | 2023/11/15

REPOSITORIES: GEO