Gene expression profile of murine thymic B cells in the presence or absence of CD40 signaling

ABSTRACT: The thymus contains some B cells that are located at the corticomedullary junction. We found that these thymic B cells express and present the water channel protein AQP4 and are necessary and sufficient to mediate the negative selection of AQP4-reactive thymocytes. In order to express and present AQP4, thymic B cells need to be licensed through a CD40 signal. Here, we tested the significance of CD40 signaling in thymic B cells for the expression and presentation of distinct autoantigens (besides AQP4) to orchestrate thymocyte selection for these autoantigens.

ORGANISM(S): Mus musculus

PROVIDER: GSE244363 | GEO | 2023/12/20

REPOSITORIES: GEO