Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells
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ABSTRACT: Aneuploidy, a near ubiquitous genetic feature of tumors, is a context-dependent driver of cancer evolution, but the mechanistic basis of this role remains unclear. By inducing heterogeneous aneuploidy in non-transformed human colon organoids (colonoids), we investigate how the effects of aneuploidy on cell growth and differentiation may promote malignant transformation. Here, we use single-cell RNA sequencing to identify the karyotype heterogenous aneuploid cells and analyze their gene expression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE244559 | GEO | 2023/10/10
REPOSITORIES: GEO
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