WNK2 regulates the response to hyperosmotic stress in chondrocytes

ABSTRACT: How chondrocytes of the synovial joint sense and respond to hyperosmotic stress to maintain joint homeostasis over time is undetermined. The With-No-Lysine (K) (WNK) protein kinases are major intracellular sensors of hyperosmotic stress that respond by regulating ion channel activity and signaling pathways. To determine if WNK2 is a hyperosmotic sensor in chondrocytes and to identify the genes and pathways regulated by WNK2, we examined the molecular response of chondrocytes to WNK2 overexpression and hyperosmotic stress.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244584 | GEO | 2024/08/01

REPOSITORIES: GEO