Dysregulated gene expression in human rheumatoid arthritis-associated interstitial lung disease(RA-ILD) and rheumatoid arthritis (RA) peripheral blood samples

ABSTRACT: RA-associated interstitial lung disease (RA-ILD) is an increasingly recognized extra-articular manifestations (EAMs) in the RA, with highly morbidity and mortality. Due to the etiology of RA-ILD is unknown, we collected peripheral blood samples of RA-ILD and RA patients. Differential gene expression analysis was employed to identify key genes, common pathways, and potential drug targets for RA-ILD. Furthermore, RT-qPCR was conducted to verify potential biomarkers in RA-ILD.This study was undertaken to understand the disease's molecular basis better and provide relevant insight into phenotypical alterations and mechanisms involved in RA-ILD pathogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244596 | GEO | 2026/10/01

REPOSITORIES: GEO