ScRNA-seq + TCR-seq of mouse polyclonal CD4+ T cells during blood-stage malaria infection.

ABSTRACT: Blood-stage malaria infection induces differentiation of several effector CD4 + T subsets including Tfh and Th1 cells. The cues and microarchitectural niches required in secondary lymphoid organs for their formation were previously uncharacterised. Here we used scRNA-seq to profile CD4+ T cell transcriptomes upon malaria infection as a reference dataset for deconvolution of spatial transcriptomic data.

ORGANISM(S): Mus musculus

PROVIDER: GSE244805 | GEO | 2024/07/08

REPOSITORIES: GEO