Transcriptomics

Dataset Information

0

Gene expression data from C57BL/6J mice exposed to 3 days of hypoxia


ABSTRACT: Pulmonary hypertension (PH) is a chronic vascular disease characterised, amongst other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. Oxidants induce cell cycle arrest to halt proliferation; however, little is known about the redox-regulated effector proteins that mediate these processes. Here, we report a novel kinase-inhibitory disulfide bond in cyclin D-CDK4 and investigate its role in cell proliferation and PH. We used an Affymetrix microarray to look at the gene expression profile of mouse lungs exposed to normobaric hypoxia (10% oxygen) or normoxia and identified genes that were differentially expressed in response to hypoxia.

ORGANISM(S): Mus musculus

PROVIDER: GSE244830 | GEO | 2023/10/31

REPOSITORIES: GEO

Similar Datasets

2021-07-02 | GSE151884 | GEO
2010-05-07 | E-GEOD-15894 | biostudies-arrayexpress
2009-10-10 | GSE9400 | GEO
2020-10-19 | PXD019039 | Pride
2020-10-19 | PXD021191 | Pride
2012-09-15 | E-GEOD-39492 | biostudies-arrayexpress
2022-08-29 | PXD033941 | Pride
2013-06-18 | GSE48002 | GEO
2022-09-01 | GSE183908 | GEO
2020-10-23 | E-MTAB-9541 | biostudies-arrayexpress