Epidermal Growth Factor Receptor Activation is Essential for Kidney Fibrosis Development

ABSTRACT: We found that EGFR expression increased in interstitial myofibroblasts in human and mouse fibrotic kidneys. Selective EGFR deletion in the fibroblast/pericyte population inhibited interstitial fibrosis in response to unilateral ureteral obstruction, ischemia or nephrotoxins. We used single-nucleus RNA sequencing analysis to demonstrate the role of EGFR activation in UUO model.

ORGANISM(S): Mus musculus

PROVIDER: GSE244839 | GEO | 2023/11/02

REPOSITORIES: GEO