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Edf1 control multiciliated ependymel cell associated genes expression

ABSTRACT: The development and differentiation of Multiciliated ependymal cells are crucial for brain development, with defects leading to conditions such as congenital hydrocephalus. The differentiation of MCCs depends on a unique transcriptional program. Our study shows that Edf1, previously implicated as a transcriptional co-factor, is consistently expressed during MCC development and positively regulates key genes involved in multiciliogenesis and physiological functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE244940 | GEO | 2023/12/31

REPOSITORIES: GEO

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