RNA sequencing of Patient-Derived Xenografts

ABSTRACT: Goal: Comparison of mRNA expression profiles in patient-derived xenograft primary tumors Methods: RNA sequencing performed at the High-Throughput Genomics and Bioinformatics Analysis Core at the University of Utah. Detailed procedures available in methods and DNA processing pipline sections. Results: Focus of study compared mRNA expression profiles of samples pre and post passaging in vivo. Unsupervised heirarchical clustering revealed samples clustered together appropriately. Conclusions: The PDX maintain the gene expression profiles of the original tumor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244967 | GEO | 2023/10/10

REPOSITORIES: GEO