Combinatorial interpretation of BMP and WNT allows BMP to act as a morphogen in time but not in concentration

ABSTRACT: We performed bulk RNA sequencing of cells exposed to either 300ng/ml of the ligand WNT3A for 6 or 18 hours, or 8μM of the GSK3b inhibitor CHIR99021 for 6 hours, which is commonly used as a substitute for WNT in differentiation. We observed transcriptional activation of the canonical WNT genes WNT3 and WNT10B confirming that Wnt signaling induces canonical WNTs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE245027 | GEO | 2023/10/10

REPOSITORIES: GEO