Transcriptomics

Dataset Information

0

Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations


ABSTRACT: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta and tau proteins in vulnerable brain regions. While the main pathological hallmarks of AD are shared across the sexes, a diverse array of sex differences have been documented for both AD-associated symptoms and molecular characteristics. To gain insights into AD-associated molecular changes and their sex-dependence for tau pathology in the cortex as one of the most severely affected brain regions, we performed single-cell gene activity profiling for the THY-Tau22 mouse model. By studying cell-type specific and cell-type agnostic AD-related changes and their sex-dimorphism for single genes, pathways and cellular sub-networks, we aimed to identify both statistically significant alterations and interpret the upstream mechanisms that control them.

ORGANISM(S): Mus musculus

PROVIDER: GSE245035 | GEO | 2024/02/09

REPOSITORIES: GEO

Similar Datasets

2018-10-13 | GSE110743 | GEO
2022-08-27 | GSE211834 | GEO
2020-01-14 | GSE142267 | GEO
2020-01-14 | GSE110741 | GEO
2021-02-10 | GSE126815 | GEO
2022-03-01 | PXD025301 | Pride
2022-07-16 | GSE154578 | GEO
2021-09-16 | E-MTAB-5742 | biostudies-arrayexpress
2023-03-01 | GSE221856 | GEO
2014-04-21 | E-GEOD-48350 | biostudies-arrayexpress