Transcriptomics

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Mucosal Boosting Enhances Vaccine Protection Against SARS-CoV-2 in Rhesus Macaques


ABSTRACT: A major limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against acquisition of infection with current Omicron subvariants, although they still provide protection against severe disease. It has been hypothesized that enhanced mucosal immunity will be required to block infection and onward transmission. Intranasal administration of current vaccines has proven inconsistent, suggesting that alternative immunization strategies may be required. Here we show that intratracheal boosting with a bivalent Ad26 based SARS-CoV-2 vaccine results in substantial induction of mucosal humoral and cellular immunity and near complete protection against SARS-CoV-2 BQ.1.1 challenge.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE245040 | GEO | 2024/02/14

REPOSITORIES: GEO

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