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Dietary supplement vanadyl sulfate selectively eliminates senescent cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE245165 | GEO | 2026/09/04

REPOSITORIES: GEO

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Dietary supplement vanadyl sulfate selectively eliminates senescent cells

Project description:During human evolution, lifestyles including dietary choices have had a major impact on shaping of human physiology and health, including aging. However, the underlying mechanisms remain largely unknown. Here, we use a blood nutrient compound library-based screening approach to demonstrate that dietary supplement vanadyl sulfate (VS) selectively induces cell death in senescent cells and ameliorates phenotypes of aging and age-related disorders in vivo. Integrated chemical biology and multi-omics studies reveal that senescent cells are specifically sensitive to VS due to reduced cysteine reactivity with accumulated glutathione disulfide. VS selectively inactivates reactive cysteines on proteins to induce formation of incorrect disulfide bonds in senescent cells with imbalanced cellular redox status, causing aberrant protein misfolding and aggregation and eventual cell death. Our findings uncover a new senolytic mechanism to mitigate age-related disorders and reshape human physiology.

2025-09-22 | GSE243912 | GEO

Dietary supplement vanadyl sulfate selectively eliminates senescent cells [16S]

Project description:During human evolution, lifestyles including dietary choices have had a major impact on shaping of human physiology and health, including aging. However, the underlying mechanisms remain largely unknown. Here, we use a blood nutrient compound library-based screening approach to demonstrate that dietary supplement vanadyl sulfate (VS) selectively induces cell death in senescent cells and ameliorates phenotypes of aging and age-related disorders in vivo. Mechanistically, integrated multi-omics strategy reveals that senescent cells are specifically sensitive to VS due to reduced cysteine reactivity with accumulated glutathione disulfide. VS strikes reactive cysteines on proteins to induce formation of incorrect disulfide bonds, causing aberrant protein misfolding and aggregation and consequent cell death. Our findings exemplify how modern-time lifestyle adaptations such as taking dietary supplements may contribute to reshape of human physiology.

2026-09-04 | GSE245164 | GEO

Dietary supplement vanadyl sulfate selectively eliminates senescent cells [RNA-Seq]

Project description:During human evolution, lifestyles including dietary choices have had a major impact on shaping of human physiology and health, including aging. However, the underlying mechanisms remain largely unknown. Here, we use a blood nutrient compound library-based screening approach to demonstrate that dietary supplement vanadyl sulfate (VS) selectively induces cell death in senescent cells and ameliorates phenotypes of aging and age-related disorders in vivo. Mechanistically, integrated multi-omics strategy reveals that senescent cells are specifically sensitive to VS due to reduced cysteine reactivity with accumulated glutathione disulfide. VS strikes reactive cysteines on proteins to induce formation of incorrect disulfide bonds, causing aberrant protein misfolding and aggregation and consequent cell death. Our findings exemplify how modern-time lifestyle adaptations such as taking dietary supplements may contribute to reshape of human physiology.

2026-09-02 | GSE243967 | GEO

Dietary supplement vanadyl sulfate selectively eliminates senescent cells

Project description:Dietary supplement vanadyl sulfate selectively eliminates senescent cells

| PRJNA1020558 | ENA

Dietary supplement vanadyl sulfate selectively eliminates senescent cells

Project description:Dietary supplement vanadyl sulfate selectively eliminates senescent cells

| PRJNA1027280 | ENA

Dietary supplement vanadyl sulfate selectively eliminates senescent cells [16S]

Project description:Dietary supplement vanadyl sulfate selectively eliminates senescent cells [16S]

| PRJNA1027288 | ENA

Dietary supplement vanadyl sulfate selectively eliminates senescent cells [RNA-Seq]

Project description:Dietary supplement vanadyl sulfate selectively eliminates senescent cells [RNA-Seq]

| PRJNA1020814 | ENA

Targeting nucleoporin 214 selectively eliminates leukemia stem cells by inducing ferroptosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-07-28 | GSE273655 | GEO

Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.

Project description: Not available

| S-EPMC10791569 | biostudies-literature

SmEnhancin selectively eliminates senescent cells by enhancing apoptosis

Project description:Four groups of cells, including the control LO2 group, the senescent LO2 group, and the 100 nM SME-treated control or senescent LO2 for 24 h group, were lysed by RIPA lysis buffer (Cat# P0013K, Beyotime, China) added with Protease inhibitors cocktail, and the supernatant was added to acetone in a 1:5 vol at -30℃ for precipitation and dissolved with 8 M urea.

2025-02-22 | PXD061114 |

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