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ABIN1 is a negative regulator of effector functions in cytotoxic T cells

ABSTRACT: The main objective of the data analysis presented here is the investigation of the role of ABIN1 in antigenic responses of primary T cells. For this purpose, T cells from ABIN1-deficient mouse strain (GTKO) and WT mice were analyzed under different activation conditions. The effect of P38 MAPK inhibitor SB203580 (p38 inhibitor/p38i) was also analyzed. The results suggest that ABIN1 is a negative regulator of TCR-mediated activation and expression of the key effector molecules in primary CD8+ T cells, at least partly via the inhibition of the p38 pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE245397 | GEO | 2023/11/01

REPOSITORIES: GEO

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