Alternative splicing of ALDOA determines tamoxifen resistance in breast cancer

ABSTRACT: Via analyzing the landscape of AS events in primary and relapse breast tumors from patients receiving tamoxifen-based therapy, it was revealed that exon skipping (ES) of exon 7.2 in 5’UTR of ALDOA pre-mRNA is associated with tamoxifen resistance. Therefore, RNA Sequencing is performed for MCF7-TAMR cells infected with ctr or ALDOA shRNAs to identify the molecular mechanism of ALDOA in mediating TAM resistance in breast cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE245500 | GEO | 2024/02/26

REPOSITORIES: GEO