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IL-4-mediates Pro-Regenerative Cellular Reprogramming in 3D Liver Culture

ABSTRACT: This study highlights the proregenerative effects of interleukin-4 in a 3-dimensional liver tissue culture platform. Interleukin-4 supplementation induces a myeloid cell phenotype shift, expands hepatocyte and cholangiocyte progenitors and inhibits fibroblast activation. Our findings open new avenues for cytokine-based therapies to stimulate immune-driven liver regeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE245659 | GEO | 2025/09/26

REPOSITORIES: GEO

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