Genetic rescue of mitochondrial complex I reverses metabolic defects in circadian mutant mice

ABSTRACT: We used single nuclei RNA-seq to compare gene expression from adipocyte circadian mutant mice +/- expression of the yeast NADH dehydrogenase (NDI1). We used RNA-sequencing of fractionated adipocytes from the visceral white adipose tissue of control mice, mice lacking the circadian clock activator Bmal1, and mice lacking the mitochondrial complex I subunit Ndufs2.

ORGANISM(S): Mus musculus

PROVIDER: GSE245850 | GEO | 2026/01/05

REPOSITORIES: GEO