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Transcriptional response of ovarian cancer cell lines to HGF and CDDP

ABSTRACT: HGF sensitizes ovarian cancer cells to chemotherapeutics, e.g. cisplatin (CDDP), through a signaling cascade activated by its MET oncogene encoded receptor and transduced by the p38MAPK. This cascade results in the regulation of a common set of transcripts in three ovarian cancer cell lines, with different genetic profiles and susceptibility to drugs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE24589 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA133587

REPOSITORIES: GEO

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Transcriptional response of ovarian cancer cell lines to HGF and CDDP

Project description:HGF sensitizes ovarian cancer cells to chemotherapeutics, e.g. cisplatin (CDDP), through a signaling cascade activated by its MET oncogene encoded receptor and transduced by the p38MAPK. This cascade results in the regulation of a common set of transcripts in three ovarian cancer cell lines, with different genetic profiles and susceptibility to drugs. In order to elucidate the mechanism of HGF dependent cell sensitization to drugs, the transcriptional response of the three ovarian cancer cell lines to HGF and CDDP were studied by microarray based transcription profiling

2013-12-31 | E-GEOD-24589 | biostudies-arrayexpress

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