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Whole transcriptome analysis after TGF-β treatment in FaDu cells

ABSTRACT: Several long non-coding RNAs (lncRNAs) are differentially expressed in oral cancer, contributing to Oral squamous cell carcinoma (OSCC), an aggressive cancer of the head and neck region. A dysregulated Transforming growth factor-beta (TGF-β) pathway is often observed in OSCC, leading to increased proliferation, migration, invasion, and chemoresistance in OSCC cells. The role of TGF-β regulated lncRNAs in promoting malignancy has already been established in multiple cancers. Such differentially expressed lncRNA involved in cross-talks with the TGF-β pathway is also reported in OSCC. We suspect many such lncRNAs function downstream of the TGF-β pathway in OSCC. We use whole transcriptomic sequencing to identify lncRNAs which are induced upon TGF-β treatment in OSCC via SMAD dependent or SMAD independent pathways to promote OSCC pathogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE246109 | GEO | 2025/09/09

REPOSITORIES: GEO

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