Project description:We measured chromatin accessibility using ATAC-sequencing for HCI-011 PDX model and HCI-003 PDX model with or without treatment of giredestrant.
Project description:We measured gene expression using RNA-sequencing for HCI-011 and HCI-003 PDX models with or without treatment of giredestrant (GDC-9545).
Project description:We measured gene expression using RNA-sequencing for MCF-7 cells with and without knockdown of ER using siRNA, compared with giredestrant (GDC-9545) treatment. NTC refers to non-targeting control.
Project description:We measured gene expression using RNA-sequencing for MCF-7 cells treated with vehicle (DMSO), GDC-9545 or GNE-858. GNE-858 is a non-ER degrader (SERM) from the same chemical series as GDC-9545.
Project description:We measured chromatin accessibility using ATAC-sequencing for MCF-7 cells treated with vehicle (DMSO), GDC-9545 or GNE-858. GNE-858 is a non-ER degrader (SERM) from the same chemical series as GDC-9545.
Project description:We measured gene expression using RNA-sequencing for MCF-7 cells with and without CRISPR-Cas9-mediated knockout of ER or FOXA1, and in the presence of vehicle or giredestrant (GDC-9545) treatment. RNP is ribonucleoprotein. NTC is non-targeting control.
